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Vagus nerve stimulation and depression - depression


Vagus Nerve Stimulation for Ever-present or Treatment-Resistant Depression

About Vagus Nerve Stimulation(VNS)

VNS is not brain surgery, though it is a conduct that affects the behave of the brain. Vagus Nerve Stimulation uses certain stimulation of the vagus nerve to send stimulation to detail parts of the brain that are concerned in mood. It is not like Electro-Convulsive Therapy (ECT), a behavior that involves stimulation of the complete brain and induces convulsions in patients. In fact, patients may not even feel the stimulation from VNS since the vagus nerve does not have the type of nerves that carry pain signals. Nor does VNS interfere with drugs, and patients having Vagus Nerve Stimulation can carry on charming their other drugs devoid of disquieting about side belongings or interactions concerning drugs.

What is the Vagus Nerve ?

Vagus means "wandering" in Latin, and is the complete account for the vagus nerve, the best ever nerve in the body. It averages just about two feet in duration and "wanders" all through the upper body. The vagus nerve starts in the brain, goes down the neck and into the body where if affects the vocal cords, the acid comfort of the stomach, the heart, the lungs, and other organs. In the brain it projects to areas alleged to be answerable for seizures, mood, appetite, recollection and concern (note 3). However, the vagus nerve cord does not have many pain nerves, so stimulation of the vagus nerve is not painful, while some patients may feel some sensation when electrical pulses are generated.

The Annals of Vagus Nerve Stimulation

Vagus Nerve Stimulation has been used to treat epilepsy patients for years; the first human clinical trial was in 1988,(note 1) and the FDA official VNS therapy for epilepsy in 1997 (note 2). So far over 22,000 associates worldwide have had VNS therapy (note 3), and it has proven to be a safe and efficient conduct for epilepsy. These patients have reported negligible side effects, which have tended to decline over time. The effectiveness of the care has also been shown to amplify with longer action time (note 1).

When Vagus Nerve Stimulation was first official for epilepsy, some patients reported an advance in mood. Researchers certain to aim a study explicitly to assess changes in a patient's mood and depression due to stimulation of the vagus nerve. In 1999, scientists began the first open label (no panacea group) study for depression with 60 patients. This first study found that there was certainly an advance in mood for depressed patients. Based on this study, a more exhaustive and thorough study was intended to clarify if Vagus Nerve Stimulation would be a safe, all right and helpful behavior for frequent depression.

The in recent times accomplished one-year, bend in half blind, sop illegal trial had 235 patients from 21 participating hospitals in the United States, and showed clinically important improvements due to action compared to baseline (note 2). The acute (short-term) phase lasted three months, all through which half of the patients established stimulation (treatment group) and half did not (control group). The long-term phase of the study lasted an further 9 months (for one year total treatment) of stimulation. The HRSD-24 (24 item clinician-rated Hamilton Rating Scale for Depression) improvements practical over the first year were approvingly significant. The outcome of this long-term, critical study were submitted to FDA in October 2003; the FDA's assessment on the use of Vagus Nerve Stimulation for depression is not anticipated ahead of October 2004 (note 2). Of note, Vagus Nerve Stimulation therapy was official for use in patients with action dead set against depression in the European Union in March 2001, and in Canada in April 2001 (note 2) .

How Does Vagus Nerve Stimulation Therapy work ?

The Pulse Generator (battery) delivers a small sum of electrical flow to the vagus nerve irregularly (30 seconds on and five follow-up off ) (note 3) 24 hours a day, 7 days a week for up to 10 years. The stimulation is delivered automatically, so the tolerant does not have to do anything. As there is nonentity to remember, acquiescence is assured. The stimulation is not believed to be uncomfortable, and some patients do not even feel the stimulation. A nurse at the doctor's company can alter the level of stimulation (amount of electricity delivered) if the tolerant ever feels uncomfortable. In the study presently being reviewed by the FDA, researchers noted numerous similarities amid epileptic and depressed patients (note 4).

One of the most crucial similarities is that Vagus Nerve Stimulation care efficiency improves over time. The longer the serene receives stimulation, the beat the results. In addition, both populations of patients share the following:

Assured loyalty to action regimen
Safety of the procedure
Safety of the therapy
High carry-over rates
No drug interactions

What is the surgery like?

Vagus Nerve Stimulation is NOT brain surgery, even all the same it is an omnipresent surgical formula that changes the do of the brain. The stimulator is a pacemaker-like contraption that generates electrical pulses (Pulse Generator); it is fixed under the skin in the left chest all through a small incision. While this may sound like a critical or hazardous procedure, it is not. The FDA has official the use, and deep-rooted the wellbeing of this procedure, and 22,000 patients have conventional the establish to treat epilepsy. The Vagus Nerve Stimulation surgery involves two small incisions, one in the chest and one at the buck part of the neck. At no time is the brain physically manipulated by the surgeon.

The surgery to instill the NCP Approach takes 45 action to two hours. Local, regional or broad anesthesia (putting the serene to sleep) is used at some stage in the surgery; the physician and anesthetist clarify which type of anesthesia is best for each patient. Most Vagus Nerve Stimulation patients will have outpatient surgery, (note 3) but some patients may need to stay in the infirmary overnight, and in that case they will need a category component or companion to take them home from the hospital.

Learn more about this remarkable appliance at www. VagusNerveStimulator. com

Charles E. Donovan


Out of the Black Hole: The Patient's Guide to Vagus Nerve Stimulation and Depression

http://www. VagusNerveStimulator. com


Can Mindfulness Help When You're Depressed?  Greater Good Science Center at UC Berkeley

Depression Can Take Hold for Struggling Dairy Farmers  Pulitzer Center on Crisis Reporting

Why Is America So Depressed?  The New York Times

Mental health stigma, depression presentations set  Kennebec Journal & Morning Sentinel

When Depression Is Like a Cancer  The New York Times

Dark Chocolate for Depression  Psychiatric Times

Battling Depression from the C-Suite  Harvard Business Review

Pregnant and Depressed  The Atlantic

Does Grandpa Have Depression?  Scientific American

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